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Progesterone Cream


Progesterone is a type of hormone produced mainly in the ovaries whose role it is to help regulate menstruation and pregnancy. During menopause, progesterone levels will drop precipitously, triggering a cascade of physical and emotional symptoms. The depletion can also lead to bone loss and the deterioration of skin elasticity, firmness, and strength. Progesterone cream may help improve the lives of women with menopause by:

  • Reducing hot flashes and vaginal dryness
  • Fighting fatigue
  • Improving mood and sleep
  • Alleviating skin dryness, wrinkling, and thinning
  • Preventing the loss of bone density (osteopenia)
  • Increasing libido
  • Fighting weight gain

Despite the health claims, research into the use of progesterone cream has yielded mixed and often contradictory results


Progesterone cream is a form of hormone replacement therapy (HRT) designed to help relieve menopausal symptoms, reduce signs of skin aging, and prevent bone loss that could lead to osteoporosis. Progesterone cream is available over the counter and made with natural plant-based progesterone derived from either soybeans or wild yam (Dioscorea villosa).1 It may be a viable alternative to the progesterone pills, suppositories, vaginal gels, and trans dermal patches commonly used for HRT, especially among women who want to avoid synthetic progesterone.


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